GLP-1 Drug Users Significantly Reduce Physical Activity, Raising Muscle Loss Concerns
A study presented to the Endocrine Society found that people taking GLP-1 medications like Ozempic and Wegovy significantly reduced their daily step counts and time spent in moderate-to-vigorous physical activity. Researchers say the decline in exercise, combined with the known muscle-loss effects of these drugs, poses a serious long-term health risk.
People taking GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are significantly cutting back on physical activity, according to a study presented to the Endocrine Society in June 2026 and highlighted in new analyses published this fall.
Researchers used Fitbit data from nearly 2,000 patients and found that GLP-1 users substantially reduced their daily step counts and time spent in moderate-to-vigorous physical activity after starting the medications. The decline was consistent across age groups and body weight categories.
The finding is particularly concerning because GLP-1 drugs are already known to cause loss of lean muscle mass alongside fat. When patients also reduce their physical activity, the combination can accelerate muscle deterioration, which affects strength, mobility, and long-term metabolic health.
Experts say the drop in activity may be partly explained by reduced appetite and lower energy levels that some patients experience on GLP-1 therapy. Others suggest that patients may feel less motivated to exercise once they begin losing weight through medication alone.
Clinical researchers are calling for targeted interventions to keep GLP-1 users physically active. Several health systems are now pairing GLP-1 prescriptions with structured exercise programs and regular check-ins with physical therapists or fitness coaches.
The study adds nuance to the broader conversation about GLP-1 medications, which have been widely praised for their effectiveness in treating obesity and type 2 diabetes. Researchers say the drugs remain valuable tools but should be paired with lifestyle support to preserve muscle health and maximize long-term outcomes.
