Perimenopause Is a Key Window for Cardiovascular Risk Prevention, New Study Says

Perimenopause may be the best time for women to address cardiovascular risk, according to a study reported by Healthline on May 23, 2026.

Researchers describe perimenopause as a "window of opportunity" for women to reassess their heart health and make changes before risk factors worsen. The hormonal shifts that occur during this phase, including declining estrogen levels, can accelerate changes in cholesterol, blood pressure, and body composition.

The study found that women who made lifestyle changes during perimenopause, including improving diet, increasing physical activity, and managing stress, saw better long-term cardiovascular outcomes than those who waited until after menopause.

Doctors say the findings reinforce the need for more proactive screening during this life stage. Many women are not routinely assessed for cardiovascular risk during perimenopause, even though the biological changes are well documented.

"This is not a time to wait and see," said one cardiologist quoted in the Healthline report. "The window is real, and it closes."

Cardiovascular disease is the leading cause of death among women in the United States. Despite that, women are often underdiagnosed and undertreated compared to men.

The study adds to a growing body of research on women's heart health across the lifespan. Earlier this year, separate research suggested that women may need to exercise more than current guidelines recommend to achieve the same cardiovascular benefits as men.

Researchers called for updated clinical guidelines that specifically address cardiovascular screening and intervention during perimenopause.