Scientists Identify Protein That Inhibits Chronic Inflammation Linked to Aging
Scientists identified a protein that appears to inhibit chronic inflammation associated with aging. Older mice with increased levels of the protein showed improved strength and energy. Researchers say the finding could eventually lead to treatments that slow age-related decline in humans.
Scientists have identified a protein that appears to inhibit chronic inflammation associated with aging. In animal studies, older mice with increased levels of the protein showed improved strength and energy compared to control groups.
Chronic low-grade inflammation, sometimes called inflammaging, is linked to a wide range of age-related conditions including heart disease, diabetes, Alzheimer's disease, and cancer. Reducing this inflammation is a major focus of longevity research.
The protein works by suppressing inflammatory signaling pathways that become overactive as cells age. Researchers found that boosting the protein's levels in older mice reduced markers of inflammation and improved physical performance.
"This is a promising target," said one of the study's authors. "We are not ready to translate this to humans yet, but the mechanism is compelling."
The finding is one of several recent advances in aging research. Scientists have also identified a topical drug, ABT-263, that improves wound healing in older skin by removing damaged senescent cells. Separate research found that microscopic gut particles may drive inflammation and chronic diseases related to aging.
A four-week dietary change, reducing fat intake or shifting to plant-based options, made some older adults appear biologically younger in a recent study. Researchers said the finding suggests that diet can influence biological aging markers relatively quickly.
The longevity research field has attracted significant investment in recent years. Several biotech companies are developing drugs and therapies targeting the biological mechanisms of aging, with the goal of extending healthy lifespan rather than just treating individual diseases.
Experts caution that results in animal studies often do not translate directly to humans. Clinical trials in people are needed before any of these findings can be turned into treatments.
